Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BABT (1) BJMBR (1) Autor Achaval,M. (1) Back,F.P. (1) Ding,Lei (1) Hermel,E.E.S. (1) Ilha,J. (1) Michaelsen,S.M. (1) Netto,C.A. (1) Pagnussat,A.S. (1) Wang,Houlei (1) Wu,Jingping (1) Zeng,Qingmin (1) Zhang,Xinchao (1) Mais... Palavra-chave Peripheral nerve injury (2) ANA (1) Functional recovery (1) Heregulin-1β (1) Median nerve (1) MiR-21 (1) Nerve morphometry (1) SKP-SC (1) SOX2 (1) Ulnar nerve (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 2012 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Effect of skilled and unskilled training on nerve regeneration and functional recovery BJMBR Pagnussat,A.S.; Michaelsen,S.M.; Achaval,M.; Ilha,J.; Hermel,E.E.S.; Back,F.P.; Netto,C.A.. The most disabling aspect of human peripheral nerve injuries, the majority of which affect the upper limbs, is the loss of skilled hand movements. Activity-induced morphological and electrophysiological remodeling of the neuromuscular junction has been shown to influence nerve repair and functional recovery. In the current study, we determined the effects of two different treatments on the functional and morphological recovery after median and ulnar nerve injury. Adult Wistar male rats weighing 280 to 330 g at the time of surgery (N = 8-10 animals/group) were submitted to nerve crush and 1 week later began a 3-week course of motor rehabilitation involving either "skilled" (reaching for small food pellets) or "unskilled" (walking on a motorized treadmill)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Peripheral nerve injury; Functional recovery; Median nerve; Ulnar nerve; Nerve morphometry. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000800010 Heregulin-1β Promotes the Synergistic Effect Between Allogenic Skin-Derived Precursor Differentiated Schwann Cells (SKP-SC) and Acellular Nerve Allograft (ANA) in Peripheral Nerve Regeneration Through Inhibiting Mir-21 BABT Wang,Houlei; Wu,Jingping; Zhang,Xinchao; Ding,Lei; Zeng,Qingmin. Previous studies in our lab found that heregulin-1β with SKP-SCs (neurons and Schwann cells differentiated from SKPs) / ANA (acellular nerve allograft) transplantation represented a powerful therapeutic approach, and facilitates the efficacy of ANA in peripheral nerve injury. In this study, our purpose is to explore the mechanism between them. Firstly we transplanted ANA + SKP-SC + heregulin-1β into rats with right sciatic nerve injury and then detected the miR-21 and SOX2 (SRY-like HMG box 2) levels. Then we transfected miR-21 inhibitor in SCs (Schwann cells) which induced in hypoxic condition before harvesting. Then we detected expression of miR-21 and SOX2 using real time-PCR and western blot assay. Results in vivo showed that the expression of miR-21... Tipo: Info:eu-repo/semantics/article Palavras-chave: Peripheral nerve injury; ANA; SKP-SC; Heregulin-1β; MiR-21; SOX2. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100321 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco